Activation of PPARA-mediated autophagy reduces Alzheimer disease-like pathology and cognitive decline in a murine model
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چکیده
منابع مشابه
YXQN Reduces Alzheimer’s Disease-Like Pathology and Cognitive Decline in APPswePS1dE9 Transgenic Mice
Alzheimer's disease (AD) is the world's most common form of dementia, in which aggregation of amyloid-β (Aβ) is the hallmark. Unfortunately, few medicines have succeeded to completely cure AD. Yangxue Qingnao (YXQN) is a Chinese traditional medicine, and its pharmacological effect is improving cerebral blood flow. In this study, we firstly demonstrated that YXQN reduced AD-like pathology and co...
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Alzheimer's disease (AD) is a devastating condition with no known effective treatment. AD is characterized by memory loss as well as impaired locomotor ability, reasoning, and judgment. Emerging evidence suggests that the innate immune response plays a major role in the pathogenesis of AD. In AD, the accumulation of β-amyloid (Aβ) in the brain perturbs physiological functions of the brain, incl...
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Sporadic, late-onset Alzheimer disease (AD) constitutes the most frequent cause of dementia in the elderly population. AD-related pathology is often accompanied by vascular changes. The predominant vascular lesions in AD are cerebral amyloid angiopathy (CAA) and arteriosclerosis/lipohyalinosis (AS/LH). The present study was carried out to examine the coincidence of these small vessel pathologie...
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BACKGROUND High rates of leisure activity have been associated with reduced risk of Alzheimer disease (AD). OBJECTIVE To determine whether prediagnosis leisure activity modifies the rate of cognitive decline in patients with AD. DESIGN Inception cohort followed up longitudinally for a mean of 5.3 years (up to 13.9 years). SETTING Urban community. PARTICIPANTS A total of 283 patients wit...
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ژورنال
عنوان ژورنال: Autophagy
سال: 2019
ISSN: 1554-8627,1554-8635
DOI: 10.1080/15548627.2019.1596488